Thomas B Shea Selected Research

Vitamin E Deficiency

2/2006	Expression and activity of methionine cycle genes are altered following folate and vitamin E deficiency under oxidative challenge: modulation by apolipoprotein E-deficiency.
4/2005	N-acteyl cysteine alleviates oxidative damage to central nervous system of ApoE-deficient mice following folate and vitamin E-deficiency.
2/2003	Vitamin E deficiency does not induce compensatory antioxidant increases in central nervous system tissue of apolipoprotein E-deficient mice.
1/2003	Folate and vitamin E deficiency impair cognitive performance in mice subjected to oxidative stress: differential impact on normal mice and mice lacking apolipoprotein E.

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Thomas B Shea Research Topics

Disease

26	Alzheimer Disease (Alzheimer's Disease) 10/2021 - 06/2002
13	Neuroblastoma 01/2019 - 06/2002
10	Cognitive Dysfunction 10/2021 - 01/2003
6	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2009 - 04/2004
4	Dementia (Dementias) 01/2018 - 06/2002
4	Vitamin E Deficiency 02/2006 - 01/2003
3	Malnutrition (Nutritional Deficiencies) 10/2007 - 12/2002
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 03/2010 - 10/2007
2	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2005 - 03/2003
2	Avitaminosis (Vitamin Deficiency) 01/2004 - 12/2002
2	Stroke (Strokes) 03/2003 - 08/2002
2	Nervous System Diseases (Neurological Disorders) 03/2003 - 12/2002
1	Gliosis 03/2010
1	Seizures (Absence Seizure) 12/2008
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2008
1	Neural Tube Defects (Exencephaly) 01/2008
1	Peripheral Nervous System Diseases (PNS Diseases) 11/2007
1	Disease Progression 04/2005
1	Iron Overload 01/2004
1	Mental Disorders (Mental Disorder) 03/2003
1	Parkinson Disease (Parkinson's Disease) 03/2003
1	Genetic Predisposition to Disease (Genetic Predisposition) 10/2002

Drug/Important Bio-Agent (IBA)

20	Folic Acid (Vitamin M)FDA LinkGeneric 01/2015 - 08/2002
11	Methionine (L-Methionine)FDA Link 01/2012 - 01/2004
8	AntioxidantsIBA 10/2021 - 02/2003
8	ApolipoproteinsIBA 01/2010 - 10/2002
7	HomocysteineIBA 01/2009 - 06/2002
6	Vitamin E FDA LinkGeneric 12/2005 - 01/2003
5	VitaminsIBA 03/2015 - 12/2005
5	Cysteine (L-Cysteine)FDA Link 01/2015 - 01/2004
5	Acetylcarnitine (Alcar)IBA 01/2015 - 06/2002
5	Apolipoproteins E (ApoE)IBA 01/2010 - 10/2002
4	Phosphotransferases (Kinase)IBA 01/2009 - 09/2004
4	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2009 - 10/2003
3	Apolipoprotein E4IBA 01/2018 - 12/2002
3	alpha-Tocopherol FDA Link 01/2015 - 12/2008
3	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2006 - 10/2003
3	Amyloid beta-PeptidesIBA 12/2006 - 06/2002
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2013 - 10/2003
2	Amino Acids FDA Link 01/2008 - 12/2002
2	NeurotoxinsIBA 11/2007 - 10/2007
2	IronIBA 12/2005 - 01/2003
2	Glutathione (Reduced Glutathione)IBA 04/2005 - 01/2004
2	HydrolasesIBA 01/2004 - 01/2004
1	Biomarkers (Surrogate Marker)IBA 10/2021
1	cucurbitacin EIBA 01/2019
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2019
1	Tetracycline (Achromycin)FDA LinkGeneric 01/2018
1	Green Fluorescent ProteinsIBA 01/2018
1	OzoneIBA 01/2018
1	Particulate MatterIBA 01/2018
1	Trace Elements (Biometals)IBA 03/2015
1	Amyloid (Amyloid Fibrils)IBA 01/2013
1	Apolipoprotein E3IBA 01/2010
1	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 02/2009
1	Neurotransmitter Agents (Neurotransmitter)IBA 12/2008
1	Vitamin B 6IBA 12/2008
1	Mutant Proteins (Protein, Mutant)IBA 09/2008
1	Glutamic Acid (Glutamate)FDA Link 09/2008
1	Dyneins (Dynein)IBA 08/2007
1	Presenilin-1IBA 12/2006
1	Thiobarbituric Acid Reactive SubstancesIBA 12/2005
1	Glutathione Synthase (Glutathione Synthetase)IBA 04/2005
1	BuffersIBA 04/2005
1	VimentinIBA 10/2004
1	EpitopesIBA 09/2004
1	Antisense OligonucleotidesIBA 09/2004
1	2- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- oneIBA 09/2004
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 02/2004
1	Adenosine (Adenocard)FDA LinkGeneric 01/2004
1	Okadaic AcidIBA 10/2003
1	Protein Isoforms (Isoforms)IBA 10/2003
1	Calcium Channels (Calcium Channel)IBA 10/2003
1	CalciumIBA 10/2003
1	Dietary IronIBA 12/2002
1	Peptides (Polypeptides)IBA 06/2002
1	Adenosine Triphosphate (ATP)IBA 06/2002

Therapy/Procedure

4	Activities of Daily Living (ADL) 01/2016 - 12/2008
1	Drug Therapy (Chemotherapy) 01/2019
1	Therapeutics 02/2008